Stephen Pasternak


Assistant Professor, Dept of Clinical Neurological Sciences

Why I Became a Scientist

I was drawn to neuroscience by the immensity of the scientific problems.  I focused on Alzheimer’s disease because of the toll it takes on my patients.

Research Questions

Characterizing the trafficking of the Amyloid Precursor Protein and it’s interactions with the enzymes which generation of beta amyloid.

Beta-amyloid which is the toxic protein that deposits in the brains of Alzheimer’s disease patients and may cause Alzheimer’s disease. It is made by cleavage of the Amyloid Precursor Protein.  By understanding how beta- amyloid is made, we hope to understand the develop treatments for Alzheimer’s disease.

Identifying MRI markers of Alzheimer’s disease.

Currently there is no diagnostic test for Alzheimer’s disease and no way to know who will get Alzheimer’s disease.  We hope to develop techniques to diagnose


  • S.B. Degree in Chemical Engineering in June 1987, Massachusetts Institute of Technology
  • S.B. Degree in Life Sciences in June 1987, Massachusetts Institute of Technology
  • M.D., C.M. degree June 1995, McGill University Faculty of Medicine
  • Ph.D. Degree, Department of Neuroscience, May 1994 , McGill University Faculty of Medicine.


  • Neurology Training Program (Residency)  Oct 1, 2000, University of Toronto Faculty of Medicine, Toronto, ON
  • Clinical Fellowship, Clinical Investigator Training Program, Oct  2000- October 2002, University of Toronto, Toronto, ON 
  • Research Associate with Drs. Don Mahuran and John Callahan. October 2000 - December 2003, Hospital for Sick Children Research Institute, Toronto, ON


View all PubMed publications

Contact Info

Research Office:
Molecular Medicine
Robarts Research Institute
1151 Richmond Street, North
London, Ontario, Canada
N6A 5B7

Phone: 519-931-5294

Clinical Office:
Director, Cognitive Neurology and Alzheimer Research Centre
St. Joseph's Health Care London / St. Joseph’s Hospital
Department of Cognitive Neurology and Alzheimer Research Centre
Monsignor Roney Building, Suite D0-224
268 Grosvenor Street
London, Ontario, Canada
N6A 4V2

Phone: 519-646-6032
Fax: 519-646-6226
Pager: 519-680-8312