Publications
PUBMED - DR. KLEIN
2024
Arutyunov, A., Duran-Laforet, V., Ai, S., Ferrari, L., Murphy, R., Schafer, D.P., Klein, R.S. West Nile Virus-Induced Expression of Senescent Gene Lgals3bp Regulates Microglial Phenotype within Cerebral Cortex (2024) Biomolecules Vol. 14(7).
Vanderheiden, A., Hill, J. D., Jiang, X., Deppen, B., Bamunuarachchi, G., Soudani, N., Joshi, A., Cain, M.D., Boon, A.C.M., Klein, R.S. Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice. (2024) Nat Immunol. Jul;25(7):1158-1171.
2023
Cain, M.A., Klein, N., Jiang, X., Klein, R.S. Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons (2023) J. Neuroinflammation. 17;21(1):24.
Kafai, N.M., Janova, H., Cain, M.D., Alippe, Y., Muraro, S., Sariol, A., Elam-Noll, M., Klein, R.S., Diamond, M.S.. Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice. (2023) Cell Rep. Aug 29;42(8):112946.
2022
Rosen S.F., Soung A.L., Yang W., Ai S., Kanmogne M., Dave V.A., Artyomov M., Magee J.A., Klein R.S. Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue resident T cells that drive synapse elimination, (2022) Genome Med. Sep 24;14(1):108
Soung A.L., Vanderheiden A., Nordvig A.S., Sissoko C.A., Canoll P., Mariani M.B., Jiang X., Bricker T., Rosoklija G.B., Arango V., Underwood M., Mann J.J., Dwork A.J., Goldman J.E., Boon A.C.M., Boldrini M., Klein R.S. COVID-19 induce CNS cytokine expression and loss of hippocampal neurogenesis, (2022) Brain Aug 25:awac270.
Manivasagam, S., Williams, J.L., Vollmer, L.L., Bollman, B., Bartleson, J.M., Ai, S., Wu, G.F., Klein, R.S. Targeting interferon-λ signaling promotes recovery from central nervous system autoimmunity (2022) J. Immunol. Mar 15;208(6):1341-1351
Soung, A.L., Dave, V., Garber, C., Vollmer, L.L., Manivasagam, S, Klein, R.S. IL-1 reprogramming of neural stem cells limits neurocognitive recovery by maintaining a proinflammatory state. (2022) Brain, Behavior and Immunity Oct 22:S0889-1591(21)00586-9. Recommended in F1000Prime
2021
Funk, K.E., Arutyunov, A., Desai, P., White, J., Diamond, M.S., Klein, R.S. (2021) Decreased antiviral immune response within the central nervous system of aged mice is associated with increased lethality of West Nile virus encephalitis, Aging Cell. Aug;20(8):e13412
Bricker, T., Darling, T., Hassan, A., Harastani, H., Soung, A., Jiang, X., Dai, Y-N., Zhao, H., Adam, L., Holtzman, M., Bailey, A., Case, B., Fremont, D., Klein, R., Diamond, M., Boon, A. A single intranasal or intramuscular immunization with chimpanzee adenovirus vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters. (2021) Cell Reports, Jul 20;36(3):109400.
2020
Salimi, H., Cain, M.D., Jiang, X., Roth, R.A., Beatty, W., Sun, C., Klimstra, W.B., Hou, J., Klein, R.S. (2020) Encephalitic alphaviruses exploit caveolae-mediated transcytosis at the blood-brain barrier for CNS entry. mBio, Feb 11;11(1). pii: e02731-19
2019
Garber, C. Soung, A., Vollmer, L. L., Kanmogne, M., Last, A., Brown, J., Klein, R.S. (2019) T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses. Nat Neurosci. 2019 Aug;22(8):1276-1288.
Funk, K. E., Klein, R.S. (2019) CSFR1 antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis. J Neuroinflam, 2019 Jan 31;16(1):22.
2018
Garber, C.*, Vasek, M.V.*, Vollmer, L.L., Sun, T., Jiang, Xiaoping, Klein, R.S. (2018) Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via interleukin-1. Nat. Immunol., Feb;19(2):151-161. Recommended in F1000Prime
2017
Daniels, B.P., Jujjavarapu, H., Durrant, D.M., Williams, J.L., Green, R.R., White, J.P., Lazear, H.M., Gale, M., Diamond, M.S., Klein, R.S. (2017) Regional astrocyte signaling restricts pathogenesis during neurotropic viral infection. J. Clin. Invest., Jan 30. pii: 88720 Highlighted in JCI This Month, 3/2017, Recommended in F1000Prime
Klein, R.S., Voskuhl, R., Segal, B.M., Dittel, B.N., Lane, T.E., Bethea, J.R., Carson, M.J., Colton, C., Rosi, S., Anderson, A., Piccio, L., Goverman, J.M., Benveniste, E.N., Brown, M.A., Tiwari-Woodruff, S. K., Harris, T.H., Cross, A. H. (2017) Speaking out about gender imbalance in invited speakers improves diversity: an example in Neuroimmunology. Nat. Immunol. Apr 18;18(5):475-478 Recommended in F1000Prime
2016
Miner, J.J., Cao, B., Govero, J., Smith, A., Fernandez, E., Cabrera, O.H., Garber, C., Noll, M., Klein, R.S., Noguchi, K.K. Mysorekar, I.U., Diamond, M.S. (2016) Zika virus infection during pregnancy in mice causes placental damage and fetal demise. Cell 165(5):1081-91.
Vasek, M.V., Garber, C., Dorsey, D., Durrant, D.M., Bollman, B., Soung, A., Yu, J., Perez-Torres, C., Frouin, A., Wilton, D.K., Funk, K., DeMasters, B.K., Jiang, X., Bown, J.R., Mennerick, S., Robinson, J.K., Garbow, J.R., Tyler, K.L., Suthar, M.S., Schmidt, R.E., Stevens, B., Klein, R.S. (2016). A complement-microglial axis is required for synaptic loss during virus-induced memory impairment. Nature 534(7608):538-43. Recommended in F1000Prime
2015
Lazear, H.M., Daniels, B.P., Pinto, A.K., Huang, A.C., Vick, S.C., Doyle, S.E., Gale Jr., M., Klein, R.S.*, and Diamond, M.S.* (2015) Interferon lambda restricts West Nile virus neuroinvasion by tightening the blood-brain barrier. Sci Transl Med. 22;7(284):284ra59. *Co-senior and corresponding authors Recommended in F1000Prime
Yue, X., Jin, H., Liu, H., Rosenberg, A.J., Klein, R.S., Tu, Z. (2015) A Potent and Selective C-11 Labeled PET Tracer for Imaging Sphingosine-1-phosphate Receptor 2 in the CNS Demonstrates Sexually Dimorphic Expression. Org Biomol Chem. 7;13(29):7928-39.
Miner, J.J., Daniels, B.P., Shrestha, B., Proenca-Modena, J.L., Lew, E.D., Lazear, H.M., Gorman, M.J., Lemke, G., Klein, R.S., Diamond, M.S. (2015) The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity. Nat. Med. Nov 2. doi: 10.1038/nm.3974. Recommended in F1000Prime
2014
Cruz-Orengo, L., Daniels, B.P., Dorsey, D., Basak, S.A., Grajales-Reyes, J.G., McCandless, E.E., Piccio, L., Cross, A.H., Crosby, S., and Klein R.S. (2014) Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility. J Clin Invest. 2014 Jun 2;124(6):2571-84.
Williams, J.L., Patel, J.R., Klein, R.S. (2014) Targeting CXCR7 as a therapeutic strategy to promote remyelination in the adult central nervous system. J. Exp. Med. May 5;211(5):791-9.
Daniels B.P., Holman D.W., Cruz-Orengo L., Jujjavarapu H., Durrant D.M., Klein R.S. (2014) Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals. MBio. Aug 26;5(5):e01476-14. Recommended in F1000Prime
Durrant, D.M., Daniels, B.P., Pasieka, T.J., Klein, R.S. (2014) IL-1R1 Signaling Regulates CXCL12-Mediated T Cell Localization and Fate within the Central Nervous System during West Nile Virus Encephalitis. J. Immunol. 193(8):4095-106. Recommended in F1000Prime
2013
Durrant, D.M., Robinette, M., Klein, R.S. (2013) IL-1R1 is required for T cell reactivation within the central nervous system during West Nile virus encephalitis. J. Exp. Med. 210(3):503-16. Recommended in F1000Prime
2012
Patel, J.R., Wiliams, J.L., Muccigrosso, M.M., Liu, L., Sun, T., Rubin, J.B., Klein, R.S. (2012) Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentation within the adult CNS. Acta Neuropathologica 15;212(1):173-9.
2011
Cruz-Orengo, L., Holman, D.W., Dorsey, D., Zhou, L., Zhang, P., Wright, M., McCandless, E.E., Patel, J.R., Luker, G.D., Littman, D.R., Russell, J.H., Klein, R.S. (2011) CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity. J. Exp. Med. 208(2):327-39. Recommended in F1000Prime
2010
Patel, J., McCandless, E.E., Dorsey, D., Klein, R.S. (2010) CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination. PNAS 107(24):11062-7. Highlighted in Nature Reviews Neuroscience 11, 536-537, 2010.
2009
CXCR3 mediates region-specific antiviral T cell trafficking within the central nervous system during West Nile virus encephalitis. J. Immunol. 180(4):2641-9. Recommended in F1000Prime
McCandless, E.E., Budde, M., Lees, J.R., Dorsey, D., Klein, R.S. (2009) IL-1R signaling within the CNS regulates CXCL12 expression at the blood-brain barrier and disease severity during EAE. J. Immunol. 183(1):613-20. PMCID: PMC2892701.
2008
McCandless, E.E., Piccio, L., Woerner, B.M., Schmidt, R.E., Rubin, J.B., Cross, A.H., Klein, R.S. (2008) Pathologic expression of CXCL12 at the blood-brain barrier correlates with severity of multiple sclerosis. Am. J. Pathol.172(3):799-808. Recommended in F1000Prime
McCandless, E.E., Zhang, B., Diamond, M.S., Klein, R.S. (2008) CXCR4 antagonism enhances survival and decreases immunopathology within the CNS during West Nile virus encephalitis. PNAS, 105(32):11270-5. Recommended in F1000Prime.
2006
McCandless, E.E., Wang, Q., Woerner, B.M., Harper, J.M., Klein, R.S. (2006) CXCL12 Limits Inflammation by Localizing Mononuclear Infiltrates to the Perivascular Space During Experimental Autoimmune Encephalomyelitis. J. Immunol. 177(11) :8053-64.
2005
Klein, R.S., Eugene Lin, Bo Zhang , Andrew D. Luster , Judy Tollett , Melanie A. Samuel, Michael Engle , Michael S. Diamond. (2005) Neuronal CXCL10 Directs CD8+ T Cell Recruitment and Control of West Nile Virus Encephalitis. J. Virol. 79(17): 11457-66. Recommended in F1000Prime
