About Us
History
The Klein lab was originally established in 2003, at Washington University School of Medicine, as a neuroimmunology basic and translational science research program focused on the pathogenesis of neuroinflammatory diseases of the central nervous system (CNS). Work in the Klein laboratory has defined novel roles for cytokines and chemokines in the regulation of blood-brain barrier permeability to arboviruses, protective versus pathogenic leukocytes, and in neurologic sequelae of viral infections such as impaired learning and memory. In 2024, Dr. Klein joined the faculty of Western University, Schulich School of Medicine & Dentistry, as Canada Excellence Research in Neuroimmunology and Neurovirology and Professor of Microbiology and Immunology.
Our Goal
Our ultimate aim is to identify neuroimmune mechanisms, therapeutic targets, and biomarkers that can help diagnose and treat virus-induced memory disorders. Through our pioneering work with in vivo models of viral infections, we've shown how virus-driven immune responses can lead to cognitive deficits, providing a foundation for developing new interventions.
