Stroke Prevention Research
Dr. J. David Spence
&
Dr. Daniel Hackam

2008 - 2010

1. Urquhart BL, Freeman DJ, Cutler MJ, Mainra R, Spence JD, House AA. Mesna for Treatment of Hyperhomocysteinemia in Hemodialysis Patients: A Placebo-Controlled, Double-Blind, Randomized Trial. Clin J Am Soc Nephrol. 2008 Jul;3(4):1041-7. Epub 2008 Mar 12.
2. Spence JD. Pollypill: for Pollyanna. Intl J Stroke 2008; 3: 92-97.
3. Chiu B, Egger M, Spence JD, Parraga G, Fenster A. Development of 3D ultrasound techniques for carotid artery disease assessment and monitoring. International Journal of Computer Assisted Radiology and Surgery, 2008. DOI: 10.1007/s11548-008-0158-0 [Epub ahead of print]
4. Lee SW, Antiga L, Spence JD, Steinman DA. Geometry of the Carotid Bifurcation Predicts Its Exposure to Disturbed Flow Stroke. 2008 Aug;39(8):2341-7. Epub 2008 Jun 12.
5. Ozdemir O, Bussière M, Leung A, Gulka I, Lee D, Chan R, Spence JD, Pelz D. Intra-arterial thrombolysis of occluded middle cerebral artery by use of collateral pathways in patients with tandem cervical carotid artery/middle cerebral artery occlusion. AJNR Am J Neuroradiol. 2008 Sep;29(8):1596-600. Epub 2008 Jun 4.
6. Klein JH, Hegele RA, Hackam DG, Koschinsky ML, Huff MW, Spence JD. Lipoprotein(a) Is Associated Differentially With Carotid Stenosis, Occlusion, and Total Plaque Area. Arterioscler Thromb Vasc Biol. 2008 2008 Oct;28(10):1851-6. Epub 2008 Jul 3.
7. Chiu B, Egger M, Spence JD, Parraga G, Fenster A. Development of 3D ultrasound techniques for carotid artery disease assessment and monitoring. Int J CARS 2008; 3:1–10
8. Hackam DG, Duong-Hua ML, Mamdani M, Li P, Tobe SW, Spence JD, Garg AX. Angiotensin inhibition in renovascular disease: a population-based cohort study. Am Heart J. 2008 Sep;156(3):549-55. Epub 2008 Jul 21.
9. Chiu B, Egger M, Spence JD, Parraga G, Fenster A. Quantification of carotid vessel wall and plaque thickness change using 3D ultrasound images. Med Phys. 2008 Aug;35(8):3691-710.
10. Spence JD. The Importance of Distinguishing Between Diffuse Carotid Intima Medial Thickening and Focal Plaque. Can J Cardiol 2008; 24 (Suppl C): 61C-64C.
11. Nanayakkara ND, Chiu B, Samani A, Spence JD, Samarabandu J, Fenster A. A "twisting and bending" model-based nonrigid image registration technique for 3-D ultrasound carotid images.IEEE Trans Med Imaging. 2008 Oct;27(10):1378-88.
12. Chiu B, Egger M, Spence JD, Parraga G, Fenster A. Area-Preserving Flattening Maps of 3D Ultrasound Images of Carotid Arteries. Medical Image Analysis 2008; 12: 676-688.
13. Mallett C, House AA, Spence JD, Fenster A, Parraga G. Longitudinal Ultrasound Evaluation of Carotid Atherosclerosis in One, Two and Three Dimensions. Ultrasound Med Biol. 2009 Mar;35(3):367-75. 2008 Nov 7. [Epub ahead of print]
14. Vidal A, Bureau Y, Wade T, Spence JD, Rutt BK, Fenster A, Parraga G. Scan-rescan and intra-observer variability of magnetic resonance imaging of carotid atherosclerosis at 1.5 T and 3.0 T. Phys Med Biol. 2008 Dec 7;53(23):6821-35. Epub 2008 Nov 12.
15. Ozdemir AO, Tamayo A, Munoz C, Dias B, Spence JD. Cryptogenic stroke and patent foramen ovale: Clinical clues to paradoxical embolism. Journal of the Neurological Sciences 2008; 275: 121–127
16. Chiu B, Beletsky V, Spence JD, Parraga G, Fenster A. Analysis of carotid lumen surface morphology using 3-dimensional ultrasound imaging. Phys. Med. Biol. 2009; 54: 1–19
17. Bhavsar S, Nimigan A, Hackam DG, O'Gorman DB, Gan BS, Spence JD. Keloid scarring, but not Dupuytren's contracture, is associated with unexplained carotid atherosclerosis. Clin Invest Med. 2009 Apr 1;32(2):E95-102.
18. Nanayakkara ND, Chiu B, Samani A, Spence JD, Samarabandu J, Parraga G, Fenster A. Nonrigid registration of three-dimensional ultrasound and magnetic resonance images of the carotid arteries. Med Phys. 2009 Feb;36(2):373-85.
19. Cutler MJ, Urquhart BL, Freeman DJ, Spence JD, House AA Mesna for the treatment of hyperhomocysteinemia in hemodialysis patients. Blood Purif. 2009;27(3):306-10. Epub 2009 Mar 9.
20. Krasinski A, Chiu B, Spence JD, Fenster A, Parraga G. Three-dimensional Ultrasound Quantification of Intensive Statin Treatment of Carotid Atherosclerosis. Ultrasound Med Biol. 2009 Nov;35(11):1763-72
21. Chiu B, Beletsky V, Spence JD, Parraga G, Fenster A. Analysis of carotid lumen surface morphology using 3-dimensional ultrasound imaging. Physics in Medicine and Biology, 54(5): 1149-1167, 2009.
22. Fergenbaum JH, Bruce S, Spence JD, Lou W, Hanley AJG, Greenwood C, Young TK. Carotid Atherosclerosis and a Reduced Likelihood for Lowered Cognitive Performance in a Canadian First Nations Population. Neuroepidemiology 2009; 33:321–328
23. Chiu B, Krasinski A, Spence JD, Parraga G, Fenster A. Three-Dimensional Carotid Ultrasound Segmentation Variability Dependence on Signal Difference and Boundary Orientation. Ultrasound Med Biol. 2010 Jan;36(1):95-110 2009 Nov 7. [Epub ahead of print]
24. Romanens M, Ackermann F, Spence JD, Darioli R, Rodondi N, Corti R, Noll G, Schwenkglenks M, Pencina M. Improvement of cardiovascular risk prediction: time to review current knowledge, debates, and fundamentals on how to assess test characteristics. Eur J Cardiovasc Prev Rehabil. 2010 Feb;17(1):18-23. 2009 Nov 27. [Epub ahead ofprint]
25. Spence JD, Coates V, Li H, Tamayo A, Muñoz C, Hackam DG, Dicicco M, Desroches J, Bogiatzi C, Klein J, Madrenas J, Hegele RA. Effects of Intensive Medical Therapy on Microemboli and Cardiovascular Risk in Asymptomatic Carotid Stenosis. Arch Neurol. 2010 Feb;67(2):180-6 (Published online December 2009)
26. Shai I, Spence JD, Schwarzfuchs D, Henkin Y, Parraga G, Rudich A, Fenster A,Mallett C, Liel-Cohen N, Tirosh A, Bolotin A, Thiery J, Fiedler GM, Blüher M, Stumvoll M, Stampfer MJ; for the DIRECT Group. Dietary Intervention to Reverse Carotid Atherosclerosis. Circulation. 2010;121:1200-1208. [Epub ahead of print] 2010 Mar 1. PubMed PMID: 20194883.
27. House AA, Eliasziw M, Cattran DC, Churchill DN, Oliver MJ, Fine A, Dresser GK, Spence JD. Effect of B-Vitamin Therapy on Progression of Diabetic Nephropathy: A Randomized Controlled Trial. JAMA 2010;303(1 6):1 603-1 609
28. Lanktree MB, Hegele RA, Schork NJ, Spence JD. Extremes of unexplained variation as a phenotype: an efficient approach for genome-wide association studies of cardiovascular disease. In press, Circ Cardiovasc Genet Apr 2010; 3: 215 - 221.
29. Spence JD. The role of lipoprotein(a) in the formation of arterial plaques, stenoses and occlusions. Can J Cardiol. 2010 Mar;26 Suppl A:37A-40A
30. Spence JD, Hackam DG. Treating arteries instead of risk factors: A paradigm change in management of atherosclerosis. Stroke 2010, [Epub ahead of print April 23, 2010]

In Press refereed papers:

1. Spence JD. Asymptomatic carotid stenosis: mainly a medical condition. Vascular 2010; in press.
2. Spence JD. Physiologic tailoring of treatment in Resistant Hypertension. Curr Cardiol Rev 2010 in press.
3. Spence JD, Jenkins DJA, Davignon J. Dietary cholesterol and egg yolks: not for patients at risk of vascular disease. Can J Cardiol 2010, in press.

Book Chapters

1. Spence JD. White-coat hypertension is hypertension. Hypertension. 2008 May;51(5):1272. Epub 2008 Mar 31.
2. Campbell NRC, Spence JD. Stroke Prevention and Sodium Restriction. Can. J. Neurol. Sci. 2008; 35: 278-279
3. Spence JD. Stroke: Atrial fibrillation, stroke prevention therapy and aging. Nature Reviews Cardiology209; 6: 448 – 450.
4. Spence JD. Treating Hypertension in Acute Ischemic Stroke. Hypertension. 2009 Aug 6. [Epub ahead of print].

Invited Editorials/Commentary in refereed journals: