Select Publications

  1. Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN. Zeta Phosphorylation Without ZAP-70 Activation Induced By T Cell Receptor Antagonists or Partial Agonists. Science 1995; 267: 515.
  2. Madrenas J, Schwartz RH, Germain RN.  Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists.  Proc Natl Acad Sci USA 1996; 93: 9736.
  3. Madrenas J, Chau L, Smith J, Bluestone JA, Germain RN.  The Efficiency of CD4 Recruitment to Ligand-engaged TCR Controls the Agonist/Partial Agonist Properties of Peptide-MHC Molecule Ligands.  J Exp Med 1997; 185: 219.
  4. Chau LA, Bluestone JA, Madrenas J.  Dissociation of intracellular signalling pathways in response to partial agonist ligands of the T cell receptor.  J Exp Med 1998; 187: 1699.
  5. Darlington PJ, Baroja ML, Chau TA, Siu E, Ling V, Carreno BM, Madrenas J. Surface CTLA-4 Partitions Within Lipid Rafts and Relocates to the Immunological Synapse in Conditions of T Cell Inactivation.  J Exp Med 2002; 195: 1337.
  6. Madrenas J. A SLAT in the Th2 signalosome.  Immunity 2003; 18: 459.
  7. Madrenas J, Potter P, Cairns E.  Giving credit where credit is due: John Hunter and the discovery of erythrocyte sedimentation rate.  The Lancet 2005; 366: 2140.
  8. Bueno C, Lemke CD, Criado G, Baroja ML, Ferguson SSG, Rahman AKMN, Tsoukas CD, McCormick JK, Madrenas J.  Bacterial Superantigens Bypass Lck-Dependent TCR Signalling by Activating a Ga11-dependent, PLC-b-mediated Pathway.  Immunity 2006; 25: 67. (Twice highlighted in Faculty of 1000 Biology: http://www.f1000biology.com/article/id/1033930/evaluation; editorial in Science STKE).
  9. Teft WA, Kirchhof MG, Madrenas J.  A molecular perspective of CTLA-4 function. Annu Rev Immunol 2006; 24: 65.
  10. Chau TA, McCully ML, Brintnell W, An G, Kasper KJ, Vinés ED, Kubes P, Haeryfar SMM, McCormick JK, Cairns E, Heinrichs DE, Madrenas J. TLR2 Ligands on the Staphylococcal Cell Wall Down-regulate Superantigen-Induced T Cell Activation and Prevent Toxic Shock Syndrome. Nature Medicine 2009; 15: 641. (Highlighted as Exceptional Paper in Faculty of 1000 Medicine: http://www.f1000medicine.com/article/id/1161383/evaluation.  Also, paper featured in The Economist June 13/2009 issue, p.84).

For a complete list of publications click here.