Bhagirath Singh

Bhagirath Singh, Professor and Scientist Emeritus; Scientific Director, CIHR - Institute of Infection and Immunity

Why I Became a Scientist

Discovery and Innovation are key factors that could change the course of what we do and how we do it. It motivates opportunities that are important to our future and solving problems. Being a scientist and teacher allows one to contribute to this endeavour and pass on the knowledge to others.

Research Summary

The focus of our laboratory is to develop specific immune-based approaches to investigate the regulation of autoimmunity by understanding the molecular, cellular and genetic basis of the T cell-mediated immune responses. Towards this goal we investigate Mechanism of Disease prevention and Tissue regeneration in autoimmune diabetes and the role that microbes and infections play in shaping our immune system. 

Research Questions

How body’s immune cells are activated by infections and microbes?

Vaccines, Transplantation, Infection control

How we can stop the immune cells to destroy body’s own tissues in autoimmune diseases?

Prevention of autoimmune diseases such as diabetes, arthritis and cardiovascular diseases

Can body self heal from using its own cells during autoimmune diseases?

Regeneration of tissues and cells in diabetes and for transplantation

Education

M. Sc,  Ph. D.

Training

Postdoctoral fellow, University of Liverpool, Liverpool, England
Research Fellow, University of Alberta, Edmonton, Alberta.

Awards

Fellow of the Royal Society of Canada 
Fellow of the Canadian Academy of Health Sciences
Bernhard Cinader Award Lecturer, Canadian Society for Immunology, 
Banting and Best Memorial Lecturer, International Diabetes Federation 
Dean’s Award of Excellence, University of Western Ontario.

Publications

Marleau AM, Summers KL, Singh B. 2008. Differential Contributions of APC Subsets to T Cell Activation in Nonobese Diabetic Mice. J Immunol. 180:5235-49.

Mukherjee R, Chaturvedi P, Lee-Chan E, Singh B. 2008. Exogenous CLIP localizes into endocytic compartment of cells upon internalization: Implications for antigen presentation by MHC class II molecules. Mol Immunol 45: 2166-2176.

Nikoopour E, Schwartz JA, Singh B. 2008. Therapeutic benefits of regulating inflammation in autoimmunity.  Inflamm Allergy Drug Targets. 7: 203-210.

Stephens TA, Nikoopour E, Rider BJ, Leon-Ponte M, Chau TA, Mikolajczak S, Chaturvedi P, Lee-Chan E, Flavell RA, Haeryfar SM, Madrenas J, Singh B. 2008. Dendritic Cell Differentiation Induced by a Self-Peptide Derived from Apolipoprotein E. J. Immunol. 181: 6859-6871.

Zhang X, Alnaeeli M, Singh B, Teng YT. 2009. Involvement of SOCS3 in regulation of  CD11c+ dendritic cell-derived osteoclastogenesis and severe alveolar bone loss. Infect Immun. 77: 2000-2009.

French MB, Loeb MB, Richardson C, Singh B. 2009. Research preparedness paves  the way to respond to pandemic H1N1 2009 influenza virus. Can J Infect Dis Med Microbiol 20:e63-e66.

Kilgannon P, Novak Z, Fotedar A, Singh B. 2010. Junctional diversity prevents negative selection of an antigen-specific T cell repertoire. Mol Immunol 47: 1154-1160.

Nikoopour E, Schwartz J, Huszarik K, Sandrock C, Krougly O, Lee-Chan E, Singh B. 2010. Th17 polarized cells from NOD mice following mycobacterial adjuvant immunotherapy delay type 1 diabetes. J Immunol  184:4779-88.

Huszarik K, Wright B, Keller C, Nikoopour E, Krougly O, Lee-Chan E, Qin HY, Cameron MJ, Gurr WK, Hill DJ, Sherwin RS, Kelvin DJ, Singh B. 2010. Adjuvant Immunotherapy Increases {beta} Cell Regenerative Factor Reg 2 in the Pancreas of Diabetic Mice. J Immunol. 185: 5120-5129.

Nikoopour E, Sandrock C, Huszarik K, Krougly O, Lee-Chan E, Masteller EL, Bluestone JA and Singh B. 2011. Cutting edge: Vasostatin-1 derived peptide ChgA29-42 is Antigenic Epitope of diabetogenic BDC2.5 T cells in NOD mice. J. Immunol. 186:3831-3835.

Singh B, Nikoopour E, Huszarik K, Elliott JF and Jevnikar AM. 2011. Immunomodulation and Regeneration of Islet Beta cells by Cytokines in Autoimmune Type 1 Diabetes. J Interferon Cytokine Res. 31: 711-719.

Summers KL and Singh B. 2012. Gut microbes and regulatory Th17 cells in Type 1 diabetes. Immunotherapy 4: 363–364.

Contact Info

Department of Microbiology and Immunology,
    University of Western Ontario, 
    London, Ontario N6A 5C1
    Tele. 519-661-3228, FAX 519-661-4226,
    E-mail:  bsingh@uwo.ca